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Under uninflamed conditions and in the absence of pathologic corneal blood and lymphatic vessels, corneal transplantationCorneal transplantation has a “low-risk” of graft rejectionGraft rejection. However, grafts that are transplanted into pathologically prevascularized recipients show high rejection rates of more than 50%, hence the termHigh-risk keratoplasty "high-risk keratoplastyKeratoplasty” is used in such cases. Conditions that lead to high-risk keratoplastyKeratoplasty include infections, traumaTrauma, chemical insults, autoimmune conditions, history of inflammationInflammation/inflammatory disease, congenital aniridiaCongenital Aniridia, ocular surfaceOcular surface diseases, prior graft rejectionGraft rejection(s) and young recipient age. Here in this chapter, we introduce different examples ofHigh-risk keratoplasty high-risk keratoplastyKeratoplasty and novel treatmentTreatment options for (lymph)angioregression to improve graft survival following aHigh-risk keratoplasty high-risk keratoplastyKeratoplasty.

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High-Risk Keratoplasty

  • 章节

  • 发表日期：

    2025年

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  • Claus Cursiefen,
  • Björn Bachmann,
  • Mert Mestanoglu,
  • Deniz Hos

摘要

Under uninflamed conditions and in the absence of pathologic corneal blood and lymphatic vessels, corneal transplantationCorneal transplantation has a “low-risk” of graft rejectionGraft rejection. However, grafts that are transplanted into pathologically prevascularized recipients show high rejection rates of more than 50%, hence the termHigh-risk keratoplasty "high-risk keratoplastyKeratoplasty” is used in such cases. Conditions that lead to high-risk keratoplastyKeratoplasty include infections, traumaTrauma, chemical insults, autoimmune conditions, history of inflammationInflammation/inflammatory disease, congenital aniridiaCongenital Aniridia, ocular surfaceOcular surface diseases, prior graft rejectionGraft rejection(s) and young recipient age. Here in this chapter, we introduce different examples ofHigh-risk keratoplasty high-risk keratoplastyKeratoplasty and novel treatmentTreatment options for (lymph)angioregression to improve graft survival following aHigh-risk keratoplasty high-risk keratoplastyKeratoplasty.