Serum eye dropsSerum eye drops (SED) are a useful adjunctive treatmentTreatment for patients with severe ocular surfaceOcular surface disease, especially those with a compromised tear film [1–3]. Blood serum contains a large number of epitheliotrophic factors that are present in tears [3]. These factors are likely to be responsible for the therapeutic benefits observed with SED therapyTherapy [3]. For example, SED should be considered in patients who have refractory or partially responsive acute or chronic severe ocular surfaceOcular surface disease [1–4]. Transfusion medicineTransfusion medicine services in Germany and other European countries have been providing SED since the late 1990s, in UK they are available since 2003 [1–3]. SED are defined as a medicinal product. Therefore, the providing transfusion service needs to apply for an approval at the respective local medical agency. The ophthalmologist is responsible for the indicationIndication to perform a SED preparation. The investigation for donor eligibility, the blood donation itself, and the SED preparation and quality control is in the responsibility of the transfusion medicineTransfusion medicine specialist. To produce SED, the donated blood unit is processed to separate out the serum that than is transferred into sterile dropper bottles and frozen for storage (The innovative and safe process for making autologous serum eye drops. https://www.meise.com/en/products/autologus-serum-eye-drops.html ). Frozen SED have a shelf life of several months from the date of donation depending on the label of the providing service.