Abnormal corneal findings can be indicative of systemic diseasesSystemic diseases or systemic medications, sometimes making ophthalmologists the first—or even the only—clinicians to detect them. Often asymptomatic, it is important to differentiate between innocuous findings and diseases with lifelong implications for the patient. Systemic diseasesSystemic diseases with corneal involvement are classified into endocrine, metabolic, nutritional, hematologic, dermatologic, skeletal/connective tissue disorders, systemic infectious diseases, and systemic autoimmune/inflammatory diseases. Systemic medications with corneal manifestations can be categorized into drug-induced corneal depositsCorneal deposits and toxic side effects to the corneaCornea.