Fungal keratitisKeratitis is a serious eyeEye disease. Its incidence increased significantly in industrial countries such as Germany in recent years, largely due to the increased wearing of soft contact lenses (CL). The clinical presentation of fungal keratitisKeratitis is variable and cannot be clearly distinguished from other types of CL-associated keratitisKeratitis at early stages. The time required to identify the correct organism and the delay in administering the correct therapyTherapy (including early penetrating keratoplastyKeratoplasty) often result in a poor long-term outcome and a higher enucleation rate in mycotic keratitisMycotic keratitis than in other cases of microbial keratitisKeratitis. Fungal keratitisKeratitis cannot be excluded by the absence of typical clinical symptoms. Therefore, further diagnostics, including same-day in vivo confocal microscopyIn vivo confocal microscopy, are required to determine the causative agent and the resistance spectrum.