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The typical clinical appearance of acanthamoeba keratitisAcanthamoeba keratitis includes pseudodendritiformic epitheliopathy, multifocal stromal infiltrates, ring infiltrate, perineural infiltrate, broad-based anterior synechiae, secondary glaucoma, iris atrophy and mature cataract. Rare complicationsComplications are sterile anterior uveitis, scleritis, chorioretinitis and retinal vasculitis. In 83–93% of cases, acanthamoeba keratitisAcanthamoeba keratitis patients are contact lens wearers. Acanthamoeba keratitisAcanthamoeba keratitis is diagnosed by polymerase chain reactionPolymerase chain reaction (PCR), confocal microscopy, in vitro cultureCulture and histopathological examination. There are currently only case series on the safety and effectivity of medical and surgical treatmentTreatment of acanthamoeba keratitisAcanthamoeba keratitis and to date there have been no randomised controlled clinical studies. After early diagnosisDiagnosis, acanthamoeba keratitisAcanthamoeba keratitis can often be successfully treated using triple topical therapyTherapy with polyhexamide, propamidine isethionate and neomycin. Topical therapyTherapy should be continued for up to 1 year. In therapyTherapy-resistant cases corneal cryotherapy, amniotic membrane transplantationAmniotic membrane transplantation, crosslinkingCrosslinking therapyTherapy and therapeutic keratoplastyKeratoplasty can be performed.

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Acanthamoeba Keratitis

  • 章节

  • 发表日期：

    2025年

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  • Nóra Szentmáry,
  • Alan Cayless,
  • Fabian N. Fries,
  • Loay Daas,
  • Lei Shi,
  • Berthold Seitz

摘要

The typical clinical appearance of acanthamoeba keratitisAcanthamoeba keratitis includes pseudodendritiformic epitheliopathy, multifocal stromal infiltrates, ring infiltrate, perineural infiltrate, broad-based anterior synechiae, secondary glaucoma, iris atrophy and mature cataract. Rare complicationsComplications are sterile anterior uveitis, scleritis, chorioretinitis and retinal vasculitis. In 83–93% of cases, acanthamoeba keratitisAcanthamoeba keratitis patients are contact lens wearers. Acanthamoeba keratitisAcanthamoeba keratitis is diagnosed by polymerase chain reactionPolymerase chain reaction (PCR), confocal microscopy, in vitro cultureCulture and histopathological examination. There are currently only case series on the safety and effectivity of medical and surgical treatmentTreatment of acanthamoeba keratitisAcanthamoeba keratitis and to date there have been no randomised controlled clinical studies. After early diagnosisDiagnosis, acanthamoeba keratitisAcanthamoeba keratitis can often be successfully treated using triple topical therapyTherapy with polyhexamide, propamidine isethionate and neomycin. Topical therapyTherapy should be continued for up to 1 year. In therapyTherapy-resistant cases corneal cryotherapy, amniotic membrane transplantationAmniotic membrane transplantation, crosslinkingCrosslinking therapyTherapy and therapeutic keratoplastyKeratoplasty can be performed.