Acne and Rosacea

Acne and rosacea are common inflammatory skin conditions that are associated with systemic inflammation and metabolic abnormalities. Here, we review the evidence for a connection between diabetes, acne, and rosacea. Acne has been linked to type 2 diabetes and insulin resistance. The pathophysiologic basis of this connection involves hyperandrogenism and activation of the mTORC1/FoxO1 pathway. However, rosacea has a less clear link to insulin resistance. While available evidence is insufficient to recommend routine screening of all acne and rosacea patients for diabetes, management of glucose intolerance shows promise in improving the severity of skin disease. Nevertheless, future studies involving larger cohorts and randomized controlled trials need to be conducted to clarify the role of diabetes in acne and rosacea.