In the preceding chapters, we approached dermatological signs starting from their associated hematological conditions. Here we adopt an inverse perspective, beginning with the skin manifestations and tracing back to potential hematological origins. For the dermatologist, recognizing these clues paves the way to consider possible systemic involvement. Conversely, hematologists will find value in this perspective; while the primary focus might be a known hematological condition, skin manifestations might offer clues pointing towards a coexisting or alternative diagnosis. The first part of this chapter describes paraneoplastic skin diseases, highlighting their potential role as harbingers of hematological malignancies. Early recognition of these dermatological signs is paramount, as they might be the initial indicators of an underlying malignancy. Being alert to these signs ensures timely interventions and prevents diagnostic delays. The subsequent segment delves into benign hematological conditions. Diseases such as anemias, hemoglobinopathies, and disorders of coagulation often manifest as nuanced skin signs. Whether these signs accompany a malignancy or merely hint at an additional diagnosis, their recognition remains crucial for a comprehensive clinical assessment. Finally, we address the cutaneous extramedullary hematopoiesis, which is a rare entity most often associated with primary myelofibrosis, chronic myeloproliferative neoplasms, chronic hemolytic states, such as thalassemia, sickle cell anemia and certain solid tumors.