Quantitative trait lociQuantitative Trait Loci (QTL) (QTLQuantitative Trait Loci (QTL)) mapping is an important tool in sweetpotato research, contributing to the understanding of genetic architecture of various traits, including dry matter, nematode resistance, and flesh color. Early QTLQuantitative Trait Loci (QTL) work was carried out by using marker information alone via single marker analysis (SMA), or based on parent-specific linkage mapLinkage map using interval mapping (IM), composite interval mapping (CIM), and multiple interval mapping (MIM). Initially developed for inbred diploid species populations, these methods did not fully consider the complex autopolyploidAutopolyploid, outcrossing nature of sweetpotato. Technological and methodological advances made it possible to obtain integrated, fully phased genetic maps for the crop. A random-effect MIM approach that leverages identity-by-descent based on QTLQuantitative Trait Loci (QTL) genotype conditional probabilities has been employed since with increasing power and resolution. To illustrate QTLQuantitative Trait Loci (QTL) identification in sweetpotato, we used publicly available data from ‘Beauregard’ × ‘Tanzania’ full-sib family ( \(N = 315\) ) evaluated for flesh color in Peru. Several methods were able to detect two QTLQuantitative Trait Loci (QTL) on chromosomes 3 and 12 each for this trait in the same genomicGenomics regions. Despite the importance of such methods, there is need to extend existing models to account for multi-trait or multi-environment data and to evaluate their application in genomicGenomics-enabled prediction.