Rejuvenation Is on Its Way

Heterochronic parabiosis or blood plasma exchange has lately become popular models in rejuvenationRejuvenation research because they demonstrate systemic decrease of biological ageBiological age in a variety of tissues. Partial dilution of blood plasma can be equally efficient. We suggest the rejuvenationRejuvenation model of inter/intra cellular washupCellular washup for removal of damaged cellular constitutes. There are various forms of adult stem cellsAdult stem cells (ASCs), including pluripotent stem cellsPluripotent stem cells, and proliferatively active zones in the brain, muscles, heart, liver, kidney, and other tissues. These systems will obviously become the active sites in rejuvenationRejuvenation. The important point is that a cell ‘knows’ how to find the way back to pluripotency and rejuvenationRejuvenation. RejuvenationRejuvenation is a natural process. The major natural rejuvenative events in mammals occur in meiosisMeiosis/gametogenesisGametogenesis and early embryonic developmentEarly embryonic development, aimed at ridding off the load of agingAging. RejuvenationRejuvenation can occur in adult life as well, for example, via cellular reprogramming.