Routes of Administration for Carriers for Lymphatic Delivery

The administration of drugs into the lymphatic system has garnered interest over the last few years. Indeed, the lymphatic system plays a significant role in the pathophysiology of diseases such as cancer, inflammation, and metabolic disorders. There is a possibility that the administration of drugs into lymph tissues could improve the treatment of these diseases. Studies have shown that there is a decrease in the first-pass metabolism when drugs go through the lymphatic system. This ultimately leads to an increase in the amount of drug in circulation. Different nanoformulations based on lipids, such as solid lipid nanoparticles and nanostructured lipid carriers, possess distinctive qualities that make them viable candidates for lymphatic administration. Furthermore, to assist in managing disease, it is possible to provide therapy by means of drug-encapsulated colloidal carriers, particularly liposomes and solid lipid nanoparticles. In drug administration, choosing the appropriate route and target area is of utmost importance. Routes that promote lymphatic access and retain drug molecules can lower systemic toxicities and boost bioavailability of poorly soluble and unstable drugs. Routes of administration for carriers into the lymphatic system are discussed in this chapter.