Analysis of Inhaler-Based Pulmonary Drug Particles Depositions Using Coupled Discrete Phase and Eulerian Wall Film Models

The present work discusses the deposition efficacy of drug particles into human respiratory airways using the Eulerian thin film and discrete phase methods. In general pressurized metered dose inhalers, nebulizers and dry powder inhalers are the most commonly used medication techniques in pulmonary-bound diseases. The current approach assumes inhalations of tiny liquid drug particles, which create a thin layer of liquid spread once strikes along the inner surfaces of pulmonary airways. Two inhalation rates against moderate 30 breaths per minute (BPM) and heavy breathing 45 BPM are considered, and the typical particle size is assumed to be 10 µm. The simulation results suggest better drug deposition efficacy at 45 BPM compared to moderate breathing at 30 BPM. The coverage area of the thin film spread along the inner surfaces is almost two times higher at 45 BPM than the 30 BPM.