Exploration of HDL-ome During Pregnancy: A Way to Improve Maternal and Child Health

Maintaining healthy pregnancyHealthy pregnancy and ensuring favorable short-term and long-term pregnancy outcomesPregnancy outcomes are among the principal goals of modern-day healthcareHealthcare. PregnancyPregnancy brings significant healthHealth challenges for the female body, which undergoes extensive physical, hormonal and metabolic adaptations from conception to delivery. Lipid profile changes typical for pregnancyPregnancy include variations in high-density lipoprotein (HDL) cholesterolHigh-density lipoprotein (HDL) cholesterol levels, but also structural and functional modifications of these lipoprotein particles, which altogether can be defined as HDL-ome changes. Although a full range of HDL-ome alterationsHDL-ome is still undiscovered, there is a lot of evidenceEvidence indicating significant differences of HDL composition and function between healthy pregnanciesHealthy pregnancy and pregnanciesPregnancy with complications. Moreover, it has been shown that HDL-ome changes can impact pregnancy outcomePregnancy outcomes, but also maternal and child healthChild health in later life. Therefore, further efforts should be put into the developmentDevelopment of strategies, involving laboratoryLaboratory evaluation of the HDL-ome, which are aimed to improve early recognition and preventionPrevention of adverse pregnancyPregnancy course and outcomes.