The treatment of psychotrichological disorders focuses on the role of stress associated with hair disease and prioritizes the development of effective coping strategies and improvement of quality of life for patients. A variety of pharmacological agents and psychotherapeutic approaches have been implemented in the treatment of psychotrichological disorders. It is essential for dermatologists and trichologists dealing with such patients to expand their clinical acumen and therapeutic armamentarium to effectively handle the psychodermatologic component in their practice. This chapter outlines the principles of psychopharmacological treatment of patients with hair disoders based on the nature of the underlying psychopathology.