The Evolving Role of Robot Kinematics in Bio-Nanotechnology

The fusion of kinematics, a field centered on motion and geometry, with molecular biology has opened new avenues in disease diagnosis and treatment, drug development, nanomachines, nano-robots, nanotechnology, and sustainability. Despite the potential of these interdisciplinary ideas, the extensive application of advanced kinematic principles in bio-nanotechnology remains underutilized. This review paper explores the critical role of applied robot kinematics in biotechnology, particularly in the evolution and discovery of innovative bio-nanomachines and bio-nano robots over the past 25 years. By reviewing the progress within the authors’ research lab during this time leading to establishing the foundation for incorporating kinematic principles in innovative bio-nanomachines, this paper explores future trends, and issues a call to action to the robot kinematics community. Emphasizing the importance of precise kinematic approaches in understanding protein molecules’ behavior for nano machine development, we argue that the robot kinematics community remains ideally positioned to drive groundbreaking progress in bio-nanotechnology and broaden the scope of these approaches in drug design, nanomachines, and development of new architected materials.