Biomarker Development Against Infections Using Proteomics

Infectious diseases continue to represent a substantial threat to public health, significantly increasing morbidity and mortality. The development of rapid and precise diagnostic tools is critical for effective disease management and control. Proteomics, the study of a cell, tissue, or organism’s entire protein complement, has emerged as an effective tool for identifying and validating biomarkers. This chapter provides an overview of the current state of proteomics-based biomarker identification for infections. Specifically, the use of several proteomics approaches, such as gel-based and mass spectrometry-based procedures, to identify potential biomarkers for a wide range of infectious diseases. Further, the difficulties and limits associated with discovering proteomic biomarkers, as well as potential solutions, are highlighted. Finally, the future paths and potential proteomics applications in developing biomarkers for prognosis, treatment monitoring, and infection diagnosis are discussed. This chapter encourages further research and improvement in this field, ultimately leading to better patient outcomes and care.