The management of discomfort after oculofacial surgery is critical. Postoperative painPostoperative pain may be inadequately treated in approximately half of all surgical procedures, with 10% of these patients going on to suffer from long-term postoperative discomfort (Carroll et al. in J Reconstr Microsurg 29:213–222, 2013 [1]). Historically, opioid analgesics were used to manage postoperative painPostoperative pain following orbital and periorbital surgery, although the side effect profile of these medications poses serious concerns, including risks of nausea, emesis, sedation, pruritus, urinary retention, delirium, respiratory depression, and long-term dependence (Benyamin et al. in Pain Physician 11:S105–S120, 2008 [2]). Coupled with tighter prescriber legislation, enhanced awareness of these issues has resulted in a shift towards employing alternatives to narcotic analgesics in perioperative patients (Xie et al. in JAMA Ophthalmol 139:157–162, 2021 [3]). This chapter characterizes the armamentarium of agents and optimal administration practices to enhance the oculofacial surgical experience.