Operating room firesOperating room fires are a critical danger in oculofacial surgery owing to the proximity of oxygenOxygen, ignitionIgnition sources, and fuelsFuel. The best practices to reduce the risk of a surgical fire include minimizing oxygenOxygen in the surgical field, strategic draping, coordinating the use of electrocautery and laser devices, and managing fuelFuel sources such as antiseptics and draping. In the event of a fire, turning off oxygenOxygen sources is a key first step. Next steps are extinguishing the fire and removing fuelsFuel from the surgical field. Operating room firesOperating room fires are preventable and safety measures described in this chapter can forestall serious injuries.