Innovative Pharmaceutical Stabilization and Formulation Techniques for Protein Drugs and Their Influence on Sequence and Structure—Part: Process
摘要
The biopharmaceutical sector is steadily increasing, focusing on the development of peptide and protein drugs into stable biopharmaceutical drug products for the medical treatment of especially severe diseases (Kaplon H, Muralidharan M, Schneider Z, Reichert JM (2020) Antibodies to watch in 2020. mAbs12(1):1703531. Lau JL, Dunn MK (2018) Therapeutic peptides: historical perspectives, current development trends, and future directions. Bioorg Med Chem 26(10):2700–2707). However, the formulation and administration of pharmacologically relevant proteins and peptides has hitherto been limited to the parenteral administration of solutions or liquid dosage forms.