Autism and Social Behavior in RASopathies

Neurodevelopmental differences affecting social behavior, including features of autism spectrum disorder, occur more frequently among individuals with RASopathies than in the general population. Current research seeks to better understand how RAS/MAPK pathway dysregulation leads to changes within the central nervous system that in turn contribute to different patterns of social behavior. A key component of this research is to characterize the behavioral phenotype of autism in RASopathies, ensuring recognition of these features and timely, accurate diagnosis. There is also a need to identify key predictors of social challenges specific to this population and to test the efficacy of interventions targeting social skills and behavior. Finally, newer research is illuminating not only the challenges that some individuals face but also identifying unique strengths that individuals with RASopathies possess. This chapter provides an overview of current research and future directions to better understand these important aspects of neurodiversity in RASopathies.