For the production and utilization of powerfuels, particularly hydrocarbon-based power-to-liquid (PtL) fuels like kerosene and diesel, the Fischer-Tropsch (FT) synthesis is seen as an essential technology and pathway in recent and upcoming years. Starting from carbon dioxide (CO2) as a primary source for producing the fuels in a carbon neutral pathway, FT has the advantage to eliminate the oxygen molecules directly in the fuels synthesis by producing water as byproduct. The latter could be recycled for generating hydrogen through electrolysis. Also, fuel composition matches quite well to the current standards and regulations such as ASTM 7566-1 and DIN EN 15940 exist for blending hydro-processed FT syncrude product to kerosene and diesel fuel into existing turbine and motor fleet, respectively. The chapter on FT is focussing on the recent developments of reactor technology for process intensification and integration regarding CO2 activation with specific attention to volatility of the hydrogen source when hydrogen is produced from renewable electricity.