Rare Familial Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII

Hemophilia A (factor VIII [FVIII] deficiency), hemophilia B (factor IX [FIX] deficiency/Christmas disease), and von Willebrand disease (vWD) compose 95–97% of all coagulopathies. The remaining coagulation factor deficiencies, including fibrinogen, prothrombin (factor II [FII]), factor V (FV), factor VII (FVII), factor X (FX), factor XI (FXI), factor XIII (FXIII), and congenital deficiency of vitamin K-dependent factors (VKDCFDs), compose the rare coagulation disorders (RCDs). Here, we discuss the less prevalent RCDs, including FII, FV, FVII, FX, FXI, and FXIII deficiencies.