Congenital Dyserythropoietic Anemias

Congenital dyserythropoietic anemias (CDAs) are a heterogenous group of disorders which are caused by a disruption of normal erythropoiesis. Their clinical presentation, which typically involves anemia with some degree of hemolysis, ranges in severity and has overlapped with other hereditary hemolytic anemias. Management and prognosis of CDAs, however, do have some differences from other hemolytic anemias; therefore, it is important to consider this diagnosis and pursue further diagnostic testing when appropriate. Furthermore, gathering accurate diagnostic information and studying the natural history of patients with CDAs will help characterize these rare disorders and optimize treatment.