Age Dependence of Central Pressure Generalized Transfer Function: An in Silico Approach

The Generalized Transfer Function (GTF), defined as the harmonic relationship between peripheral blood pressure and aortic pressure, is typically utilized for the non-invasive estimation of Central Aortic Pressure (CAP). Accordingly, one-dimensional (1D) models have gained significant prominence in recent years due to their versatility in accurately reproducing the behavior of arterial waveforms and their low computational cost. On this basis, GTF morphology and its potential variations with age were studied, in terms of a set of digitally simulated individuals. Although the obtained GTFs were in agreement with published real measurements, the functions corresponding to age groups younger than 40 years behaved differently than those of older groups. This could indicate the convenience of considering differentiated GTFs functions in terms of the subject age (a ‘patient specific’ approach).