Mixed metal oxide (MMO) anodes have attracted interest in the scientific community due to their advantages, such as high catalytic activity, low synthesis cost, ease of preparation, and stability (K. I. B. Eguiluz, N. K. Hernandez-Sanchez, A. R. Dória, G. O. S. Santos, G. R. Salazar-Banda, and C. Ponce de Leon, “Template-made tailored mesoporous Ti/SnO2-Sb2O5-IrO2 anodes with enhanced activity towards dye removal,” J. Electroanal. Chem., vol. 910, no. February, 2022, https://doi.org/10.1016/j.jelechem.2022.116153 .). The method of synthesis of these electrodes directly influences their morphology and electrochemical properties. The calcination stage of the anode is carried out in electric ovens and is the commonly employed method for synthesizing MMO anodes (Wu et al. in Appl Catal A Gen 480:58–78, 2014). However, recent attention has been paid to microwave irradiation, which offers advantages such as rapid and selective heating, the use of smaller equipment, low electrical energy consumption, and reduced environmental pollution (Gonzaga et al. in Chem Eng Commun 206:647–653, 2019). In this study, we investigated the impact of the preparation conditions of the MMO anodes (Ti/(RuO2)0.9–(Sb2O5)0.1 and Ti/(RuO2)0.9–(TiO2)0.1) on their efficiency for color removal and chemical oxygen demand (COD) in textile effluents through an electrochemical process. Anodes were synthesized using microwave irradiation at temperatures of 350 °C and 400 °C, using the ionic liquid 2-hydroxyethylammonium acetate as the solvent for metal precursors (M. O. Santos, G. de O. S. Santos, S. Mattedi, S. Griza, K. I. B. Eguiluz, and G. R. Salazar-Banda, “Influence of the calcination temperature and ionic liquid used during synthesis procedure on the physical and electrochemical properties of Ti/(RuO2)0.8–(Sb2O4)0.2 anodes,” J. Electroanal. Chem., vol. 829, no. May, pp. 116–128, 2018, https://doi.org/10.1016/j.jelechem.2018.10.013 .). The electrochemical treatment of textile effluent was carried out in a 150 ml cell, using MMO anodes and a stainless-steel cathode. The experimental variables studied were the anode composition at its respective preparation temperature, current density (20, 40, and 60 mA/cm2), and electrolysis time (10, 20, 30, 60, 120, 180 min). All the variables studied showed different percentages of removal. The results indicate that the Ti/(RuO2)0.9–(Sb2O5)0.1 anode, synthesized at 400 °C and operated at a current density of 60 mA/cm2 for 120 min, achieved a significant reduction of 40.8% in the initial COD of the effluent (350 mg/l) and a color removal of 37.5%. This study highlights the considerable impact of anode preparation conditions on their electrocatalytic properties, especially in the generation of electrochemical oxidants and their oxidation capacity in the treatment of textile wastewater. This is relevant for a growing industry that seeks environmentally sustainable technologies.