Bovine besnoitiosis, caused by the protist Besnoitia besnoiti, impairs productive and reproductive parameters and is endemic in Western Europe, sub-Saharan countries in Africa, and in a few countries in Asia. This parasitic disease is characterized by both nonspecific systemic clinical signs during the acute phase (hyperthermia, oedemas, and orchitis in bulls) and cutaneous lesions (scleroderma) during the chronic phase. Besnoitiosis is more common in beef cattle than in dairy cattle, probably associated with extensive management practices where several risk factors are present, such as natural mating, exposure to arthropod vectors, and the presence of pastures or studs shared by multiple herds. Unfortunately, there are no therapeutic tools or vaccines available and registered in Europe for bovine besnoitiosis. Thus, the control of the disease relies on early diagnosis coupled to management measures. Serological tests allow the detection of clinically affected animals as well as subclinically infected animals. Once unproductive animals, together with sterile bulls, clinically affected cattle, and superspreaders, are eliminated from the herds, additional measures should include independent management of seropositive and seronegative cattle, surveillance of new entries, and use of repellents and ectoparasiticides indoors and outdoors.