Photoacoustic Endoscopy

In the rapidly evolving landscape of medical imaging, endoscopy emerged as a revolutionary technique, facilitating non-invasive visualization of internal body structures, and playing a crucial role in the diagnosis, treatment, and monitoring of diverse medical conditions. Photoacoustic endoscopy (PAE) is an advanced endoscopic imaging technique that evolved from photoacoustic imaging and traditional endoscopy. PAE’s high-resolution images, which reveal both functional and molecular information, are made possible through the combination of laser light with sound waves. Recent advancements in PAE include miniaturized probes and high-speed imaging capability. These are propelling its clinical translation for early disease detection, accurate diagnosis, and image-guided interventions. PAE’s potential applications are vast, and its integration with artificial intelligence and other imaging modalities holds promise for personalized medicine and comprehensive medical imaging in the future. This chapter offers an overview of PAE, encompassing its historical development and recent applications in the medical field. The fundamental principle of PAE is explored, alongside key technological advancements that have propelled its clinical utility. Additionally, the chapter delves into the applications of a typical PAE device in cutting-edge research, showcasing its potential in various medical disciplines. In conclusion, this chapter discusses current challenges in the development of PAE and its potential to reshape the medical landscape through transformative diagnostic and therapeutic possibilities.