Cryoglobulinemia
摘要
Cryoglobulinemia (CR) is a disease characterized by the presence, in the serum, of abnormal proteins that precipitate reversibly at low temperatures, and generally the cryoglobulins lead to a systemic inflammatory syndrome characterized by myalgia, arthralgia, purpura (Meltzer’s triad), neuropathy, and glomerulonephritis (Takada S, Shimizu T, Hadano Y, Mol Med Rep. 6:3-8, 2012). According to immunochemical characteristic, cryoglobulins have been classified into three distinct groups.