Skin Necrosis and Ulcers Induced by Medications

In recent decades, it has been reported for numerous medications that their systemic administration may lead to the development of skin necrosis and subsequently to ulcerations. Allergic as well as nonallergic etiologic mechanisms have been described. Most of the relevant pathological reactions induced by these medications are a type of vasculitis or vasculopathy. Although these reactions often manifest as a rash or other skin diseases, some medications can lead to the development of skin necrosis and ulcers. Therefore, in this chapter, an exemplary number of medications are presented which had been discussed to be responsible for the development of skin or mucosal necrosis and ulcers.