Introduction to Skin Necrosis of Toxic Origin

Medical toxic agents and animal or insect bites can cause skin necrosis. In addition, there are clinical and forensic signs of opioid abuse. Coma-induced blisters are a rare condition associated with prolonged impairment of consciousness levels, which is relatively well known in adults following an overdose of barbiturates. This chapter covers skin ulcers and necrosis due to medications, snakebites, jellyfish and stonefish, spider Loxosceles reclusa, scorpions, and “drugs” such as Cannabis sativa, cocaine, and heroin. It also discusses the systemic conditions of the toxic syndrome and how to resuscitate foot necrosis. Each theme can bring about a better understanding of how it develops and how to treat it properly.