Epidermolysis Bullosa

Genetic skin fragility disorders, collectively designated epidermolysis bullosa (EB), manifest with trauma-induced blistering and erosions of the skin; the most severe forms also involve the mucous membranes. Residual manifestations of skin fragility comprise pigment anomalies, epidermal atrophy, or scarring. The appendages of the skin, nails, hair, and teeth, as well as other organs may also be affected. Severe EB subtypes evolve as systemic diseases with secondary multiorgan involvement and premature death.