Two-Stage Revision Total Knee Arthroplasty for Periprosthetic Joint Infection

Difficult-to-treat infections, the number of prior surgeries, and the level of tibial bone defect forecast the failure of two-stage revision TKA (rTKA). High serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels before reimplantation in two-stage rTKA for chronic periprosthetic joint infection are associated with increased reinfection percentage after surgery. Elevation of both ESR and CRP are associated with a higher risk of reinfection compared with elevation of either ESR or CRP. The leukocyte esterase strip test in synovial fluid is a dependable method to diagnose persistence of infection. Elevated CRP levels and methicillin-sensitive Staphylococcus aureus infection are associated with failure of a two-stage rTKA.