Autoimmune Limbic Encephalitis

Autoimmune encephalitis is now being widely recognized as a common and potentially treatable cause of encephalitis. The majority of the autoimmune encephalitis cases clinically present with limbic system dysfunction. Many neural autoantibody biomarkers of autoimmune limbic encephalitis have been described, and novel antibodies are being recognized every year. These antibodies are either directed against cell surface epitopes or intracellular antigens. Learning about the specific clinical presentations of autoimmune encephalitides, their pathophysiology, and cancer association is crucial for patient care. We highlight the typical clinical and radiological features of autoimmune limbic encephalitides. We also describe the treatment strategies and immunotherapy agents utilized.