Peripheral Sensitization: Peripheral Mechanisms of Neuroma and Neuropathic Pain
摘要
Painful peripheral neuromas may occur after peripheral nerve injury and can result in pain and decreased quality of life for the patient. Regenerating axons from the proximal segment of the injured nerve become entangled in scar tissue, forming a neuroma. Nociceptors within the neuroma may become sensitized by prolonged noxious stimulation leading to hyperalgesia and allodynia. This chapter describes the mechanical, biochemical, and electrophysiological mechanisms behind peripheral sensitization and neuropathic pain of the symptomatic neuroma.