Motocross is a popular off-road motorcycling sport across the globe. Though exciting to watch, risk of injury is extraordinarily high for the participants when compared to most other sporting competitions. There are various factors to consider when evaluating the safety of this sport, including the mechanisms of injury, the types of injury and available treatments, and the effectiveness of protective equipment. While there have been advances in technologies to prevent injury or reduce injury severity, further developments will be needed to optimize the environment, thereby allowing safer participation for a wider range of athletes.