Ankle injuries are one of the most commonly seen musculoskeletal problems both in athletes and sedentary individuals. Physiotherapy and rehabilitation play a critical role to return the patients to their preinjury activity levels. Ankle injuries range from minor sprains to severe fractures, and the rehabilitation process must be designed to the injury status and patients’ needs. Nonsurgical treatment is usually the first option, and the progression may follow a very similar course as postoperative rehabilitation. The criteria for progression are based primarily on injury status, patient symptoms, and response to the treatment rather than time. The main rehabilitation goal is to restore ankle range of motion, strength, flexibility, and proprioception on the affected side, while also preventing future injuries. Manual therapy application, electrotherapy modalities, and proprioceptive neuromuscular facilitation techniques can be implemented to the program. A gradual return to sport or daily activities is the final stage of the rehabilitation program. This stage should be designed to meet the specific needs of the patient with consideration for current injury recovery status.