The biomaterials are important tools used in orthopedic sports medicine surgery and their knowledge has evolved over the last 50 years. They are suture anchors, interference screws, suture threads, scaffolds, ligament substitutes and augmentation devices. Various metals, polymers, and natural materials have been used. Suture anchors allow effective fixation of soft tissue to bone. Interference screws provide a press fit between bone, graft/tendon within a bone tunnel. Biodegradable materials made of natural, synthetic, or biosynthetic polymers such as Polyglycolic acid (PGA), Poly-L-Lactic Acid (PLLA) and copolymers like poly-D-L-lactic acid (PDLLA) maximize pullout strength, minimize acute iatrogenic damage, and minimize long-term pro-arthritic potential. Also, synthetic polymeric and hydrogel scaffolds can promote cell migration and can provide a substitution for menisc and focal cartilage defects. The development of 3D printing can provide personalized substitutes, including a promising 3D printed fibrous polycaprolactone(PCL). The synthetic grafts used in the 1980s and 1990s with the development of new polymers with surface treatment and biologic enhancement have the potential to increase the biocompatibility and biodegradability and can be an option for ligament substitution or augmentation. The fibertape (Internal BraceTM), a colagentype I coated, high-molecular-weight polyetyhilene core tape has shown to be a good option to reinforce ligament repair and reconstructions. Surface engineering with modification with cold glow discharge plasmas can enhance the properties of materials, including wettability.