Antiphospholipid Syndrome and Stroke: Diagnosis and Management

Antiphospholipid syndrome (APS) is a heterogenous, systemic autoimmune disease associated with vascular thrombosis (venous, arterial or microvascular), and/or obstetric morbidity, in the presence of persistent antiphospholipid antibodies (aPL). Acute ischaemic stroke is the most common arterial manifestation of APS. Following a case presentation of a 40-year-old patient found to have triple-positive aPL in the setting of recurrent ischaemic stroke, we discuss key clinical aspects relating to the diagnosis and management of APS, focussing on thrombotic APS with cerebrovascular involvement.