A stimulant use disorder is the use of cocaine, methamphetamine, or prescription stimulants that causes negative effects for the user, including significant impairment and/or distress. While there are multiple medications available to treat problematic use of other substances such as alcohol, tobacco, and opioids, there are no widely used medications to treat stimulant use disorders. Many medications have been studied for stimulant use disorders, with a handful demonstrating some efficacy, mostly in individual studies. However, none of these medications has robust enough evidence to support them to the point that they have gained regulatory approval and/or professional consensus to support their use. Notably, given some promising evidence in the studies that have been done, medication options may reasonably form part of a treatment discussion with a patient interested in reducing or stopping their stimulant use alongside other non-medication options.