Harm reduction in clinical practice is an approach to working collaboratively with patients to reduce the harmful consequences of behaviors. The modern and mainstream spread and adoption of the harm reduction approach in the United States is rooted in a history of grassroots organizing, activism, and mutual aid that occurred during the HIV/AIDs epidemic in the 1980s. In the harm reduction model, abstinence from substance use or complete elimination of a harmful behavior is not the required goal and therefore allows the practitioner to “meet the patient where he/she is.” When practicing harm reduction, it is important for clinicians to foster a sense of autonomy and individualism. Any changes that reduce harm or improve health are supported and can be celebrated in harm reduction-based treatment settings. Using a biopsychosocial model, harm reduction can be practiced across different settings and can focus on many different types of potentially harmful behaviors. The practice of harm reduction can involve the use of various interventions including medications (e.g. medications to treat opioid use disorder), needle exchange programs, and naloxone opioid overdose response kits. Many different psychotherapeutic interventions can be used in harm reduction, such as Motivational Interview (MI) or Cognitive Behavioral Therapy (CBT).