Glutathione Precursors Supplementation Effects on Renal Function, Lipid Profile and Body Composition

Glutathione (GSH) helps to reduce the production of oxidative stress in our body caused by metabolic syndrome (MS) condition. While oral GSH is bioavailable in laboratory animal models, its efficacy effect in humans has vast opportunities to be explored. We aim to study the significance of GSH precursor’s oral supplement on volunteers for 8 weeks of daily consumption. The dosage differential of GSH precursor’s oral supplements on human blood GSH levels is also investigated. The study was conducted on 300 volunteers from Kuala Lumpur and Petaling Jaya, Malaysia. Volunteers were randomized into control and intervention groups; Group 1 (consumed 1.6 g of Immune Formulation 200®) and Group 2 (consumed 3.2 g of Immune Formulation 200®). Blood samples were collected for GSH analysis, renal function, and lipid profile. A bio-impedance analysis is conducted for body composition assessment. Statistical analysis was performed to evaluate the significant difference in the aforementioned blood component between groups. Results showed a significant increment in total GSH level after consuming oral GSH precursors supplementation, especially for subjects in Group 1. Significant changes were observed in some of the renal function parameters namely, creatinine for subjects in group 1 and sodium, carbon dioxide and creatinine for group 2 subjects. Subjects who consumed two doses of oral Immune Formulation 200® for eight weeks show substantial changes in their total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterols levels. Meanwhile, no changes were observed in body composition parameters for both group.