Enhancing the efficiency of photodynamic processes has long been a primary objective for researchers in the field, both for tumor elimination and antimicrobial photodynamic inactivation (aPDI). When reduced to the nanometer scale, metals display unique properties that differ from their bulk forms. Particularly silver nanoparticles (AgNPs), have been widely applied in areas such as food preservation, catalysis, biosensing, and drug delivery. A defining feature of metallic nanostructures is their optical behavior, particularly the localized surface plasmon resonance (LSPR) effect. In this context, the application of the plasmonic effect to amplify the photosensitizer (PS) response during its interaction with electromagnetic radiation has emerged as a promising approach. The studies presented in this chapter show the coupling of prismatic silver nanoplatelets (AgNPrs) to methylene blue demonstrating aPDI effectiveness against drug-resistant Staphylococcus aureus and Candida albicans cells. The results revealed that the use of AgNPrs reduced the light dose required for complete eradication of the microorganisms, with the effect being dependent on the PS concentration. However, further studies are required to better understand the physicochemical processes that enhance the effect, thereby advancing future investigations in this area.