Acne is a chronic inflammatory dermatosis that affects psychologically its carriers, as it presents in exposed regions such as the face, where there is a more significant number of sebaceous glands and where all the changes that cause the disease occurs, such as hyperkeratinization, increased amount of sebum, infestation by Cutibacterium acnes and inflammation. Acne treatments vary and depend on the degree of severity of the disease, and they can be used in topical cosmetics or systemic antibiotics. The treatments aim to reduce inflammation, sebum, and C. acnes bacteria. However, antibiotics have caused microbial resistance, which is no different in acne since many antibiotics used to treat the disease, even topical, cause bacterial resistance. Alternatives have been studied, such as blue light therapy, which has been successfully applied in dermatology for many inflammatory diseases and local infections, such as acne. Blue light excites endogenous porphyrins of the bacteria, producing reactive oxygen species (EROs), leading to bacterial death. Blue light also has anti-inflammatory effects. The devices used for blue light treatments are lasers and LEDs, and wavelengths range from 400 to 500 nm. Some authors report a higher bacterial death effectiveness in the 405–420 nm range. However, the most described side effect in the literature is skin hyperpigmentation. Wavelengths in the 450–470 nm range also demonstrated promising results in bacterial death. Blue light research has shown positive results in the treatment of acne. There is undoubtedly a need for more studies, primarily “in vivo,” to determine the ideal parameters that should be used, such as irradiance, wavelength, and others. Certainly, photobiomodulation, especially with blue light, is an alternative used in acne treatments, both among health professionals and people with acne who use home-use devices.