This chapter explores the potential of antimicrobial blue light (aBL) therapy as a novel approach for managing oral infections, particularly periodontal disease, oral mucosal diseases, and dental implant-related infections. aBL induces the generation of reactive oxygen species (ROS) that disrupt bacterial defense mechanisms such as antioxidant enzyme systems and biofilm formation. This leads to the inhibition of bacterial growth and replication and eventually to cell death, making aBL therapy a promising noninvasive treatment strategy. Combining aBL with traditional antimicrobial agents can enhance treatment efficacy, reduce bacterial antibiotic resistance, and minimize adverse effects. This combined approach could provide a more effective and comprehensive treatment for oral infections. The clinical applications of aBL therapy in treating periodontal disease, oral candidiasis, and peri-implantitis are highlighted, demonstrating its safety and ability to improve oral health outcomes. Future directions for aBL technology include optimizing the treatment parameters, developing portable devices, and exploring its potential for oral disease prevention. Despite this promise, challenges such as bacterial resistance and the need for further clinical validation remain. Overall, aBL technology represents a significant advancement in oral medicine, offering new therapeutic avenues for both the treatment and prevention of oral diseases.