Biomarkers of Diabetic Foot Ulcers and Its Healing Progress

There are urgent, unmet needs in the field of biomarkers of diabetic wound healing. Rapidly developing molecular technologies supported by the parallel, robust progress in biostatistical and machine learning approaches are offering more granular insights into the disease processes and unraveling potential biomarkers. These methodological and computational innovations are tremendously accelerating biomarker research. National Institute of Diabetes and Digestive and Kidney Diseases has recently funded the Diabetic Foot Consortium, the largest initiative to date aiming to develop and validate biomarkers of diabetic foot ulcers; whereas the Food and Drug Administration and the National Institutes of Health offer an important glossary of nomenclature to help researchers navigate through different types of biomarkers. Multi-molecule signatures rather than single biomarker measurements will likely guide the diabetic wound healing course in the near future.