The Role of Vitamin C in the Prevention and Treatment of Cancers
摘要
Vitamin CVitamin C is a water-soluble vitamin, and is contained in many vegetables, fruits and other foods. Vitamin C possesses many bioactivities, such as antioxidantAntioxidant and anticancerAnticancer activities. Vitamin CVitamin C shows anticancer action against many cancersCancer, such as colorectal cancer, breast cancer, pancreatic cancer, prostate cancer, lung cancer, brain cancer, thyroid cancer and so on. The underlying mechanismsMechanisms of action include producing H2O2, inducing apoptosis, causing DNA damage, increasing autophagosome, disrupting glycolysisGlycolysis, depleting ATP and other signaling pathways. In this chapter, effects and mechanismsMechanisms of vitamin C on various cancers are summarized based on the results from epidemiological, experimental and clinical studies. This chapter is helpful to use vitamin CVitamin C for the preventionPrevention and treatmentTreatment of cancersCancer.