The objective of this chapter is to deliver recommendations on how to approach, diagnose, and guide children and their families who seek a solution for nocturnal enuresis. A structured approach is given after having reviewed milestone studies and publications, as well as recently published literature of studies, reviews, guidelines regarding the etiology, diagnosis, and treatment options of nocturnal enuresis (Since 2012, a monthly literature search using Scopus® was performed and the relevant literature was reviewed and prospectively registered on the European Urology bedwetting enuresis resource center (► http://bedwetting.europeanurology.com/ ). In addition, guideline papers and statements of the European Society for Paediatric Urology (ESPU), the European Association of Urology (EAU), the National Institute for Health and Care Excellence (NICE), and the International Children Continence Society (ICCS) were used to update the knowledge and evidence resulting in this practical recommendation strategy. Recommendations have been discussed and agreed within the working group of the EAU-ESPU guidelines committee members). The recommendations focus to place the child and his or her family in a control position. Pragmatic analysis is made of the bedwetting problem by collecting voiding and drinking habits during the day, measuring nighttime urine production, and identification of possible risk factors such as high-volume evening drinking, nighttime overactive bladder, behavioral or psychological problems, or sleep-disordered breathing. The child and its family should be guided in the treatment they choose, and they should be in control at all times. Motivation of the child is important for success. Continuous involvement of the child and the family in the treatment will improve treatment compliance, success, and patient satisfaction.