Conservative treatment should be the cornerstone of female LUTS management, not only as the first stage of a stepwise approach but also as an adjunct to other treatment modalities such as pharmacological or even surgical treatment. The management of comorbid conditions and concurrent medications, counseling about lifestyle modifications and scheduled voiding regimens should be done by the urologist, nurse practitioner and dietitian. Physiotherapists may offer pelvic floor muscle therapy (including manual therapy, biofeedback, and electrical muscle stimulation) and posterior tibial nerve stimulation. Psychologists complete the multidisciplinary team by providing cognitive behavior therapy when indicated. Available pharmacological treatment is mostly directed at the storage of LUTS (antimuscarinics and Beta3-agonists) and the selection of the best medication for each case should consider patient characteristics and also drug-related factors, such as adverse effect rates. Low-dose desmopressin may play a significant role in the treatment of nocturia and topical (vaginal) estrogens have proven beneficial for post-menopausal female LUTS. The success of conservative and pharmacological treatment probably relies on adequate patient selection for each therapy and regular re-assessment of the results of each intervention. As a result, it is possible to adjust management strategies to meet patient’s needs and expectations.