How to Build a Cerebellum

The solution requires a dual-hemisphere mini brain intimately connected to the brainstem and the body (via the spinal cord), resembling though surprisingly different from the larger specialised domes of our cerebral hemispheres—the cerebellum. The cerebellum’s basic interior design is a three-layer structure that maintains its uniform regularity across the lobes of both hemispheres, accounting for the notion that cerebellar morphology is regimented and uniform. That said, the laminar structure of the cerebellum belies its microstructural complexity and the precise regional mapping of specific cerebellar zones to their targets in cortical brain regions. Let’s build our cerebellum.