Inducibility of Metabolizing Enzymes
摘要
Metabolic enzyme inducibility is of major significance, because it plays an important role in the susceptibility of individuals to foreign compound–mediated toxicities. Although some xenobiotics exhibit intrinsic toxicity, while some others are metabolically activated to potential toxicants by activation enzymes. The generated metabolites undergo detoxification enzyme–catalyzed reactions for detoxification, before foreign compounds are ready for excretion.