Proteostasis, Proteodynamics and Cellular Aging

During each cell’s life, myriads of different, necessary proteins are manufactured and serve as interacting structural and/or functional elements without which the cell could not function properly. Organismal and cellular aging imposes stresses, constrains and dysfunctions on each and every stage of protein manufacturing, maturation and maintenance, as well as on the efficiency of removal of those proteins that were malformed (e.g. misfolded) from the beginning or during life of the cell underwent modifications leading e.g. to their aggregation. Eventually, these processes, included in cellular protein homeostasis (proteostasis or proteodynamics) fail to provide enough of new, functional protein molecules characterizing young cell and the cell becomes senescent or dies.